CV

This Node Is Deprecated — This version of the node has been replaced with a new and improved version. The old version is kept for backwards-compatibility, but for all new workflows we suggest to use the version linked below.
Go to Suggested ReplacementCV

The CV is a statistical parameter that describes variance of data.

For each group of data (e.g. wells of plates) CVs are calculated for each selected subset (e.g. control wells of a plate).

CV = sd(x[subset] / mean(x[subset]) * 100
or
CV = mad(x[subset] / median(x[subset]) * 100

Literature: Zhang, J. et al., J Biomol Screen 1999; 4; 67
Wikipedia: Coefficient of variation

Options

Group wells by
Select the column to define the groups (e.g. "barcode" for plate-wise CVs).
Select subset column / well annotation column
Column with well annotations (e.g. treatment)
Choose subset(s) / well annotation(s)
Select one or many subsets for which CVs are calculated (e.g. "negative control").
Use robust statistics
Median and mad will be calculated instead of mean and sd.
Include
Select the columns for which CVs will be calculated.

Input Ports

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Input table

Output Ports

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Table with CVs

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Installation

To use this node in KNIME, install the extension KNIME HCS Tools from the below update site following our NodePit Product and Node Installation Guide:

v5.9
Plugin provider: Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
Plugin version: 5.5.0.v202511111303
On NodePit since: 2025-12-12
Last update: 2026-01-25
Tags: Deprecated
KNIME versions: v5.9, v5.8, v5.7, v5.6, v5.5, v5.4, v5.3, v5.2, v5.1, v4.7, v4.6, v4.5, v4.4, v4.3, v4.2, v4.1, v4.0, v3.7, v3.6

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