HuSSPred - Human Skin Sensitization Data - WES HMA

DSA05

PreS/MD Curation - GPMT

Select only:
- WES BIN

Level 3: Binary Only

• removes n/a
  
  

Chemical Curation

Chemical Curation

LOAD PRESSMD DATA

STopTox SS Dataset - LLNA

Chemical Curation

SARA-ICE - E. Reinke: LLNA

Binarized according to OECD 429

EC3 present = positive / sensitizer

no EC3 = negative / non-sensitizer (also annotated as >100.0 or max dose)

Data Curation Template:

SARA-ICE - E. Reinke: DPRA

https://doi.org/10.1016/j.crtox.2024.100205

OECD 442C Threshold:

• Both Cys/Lys peptides present → use mean-depletion cut-off >6.38% mean depletion threshold = active

• Only Cys: if Cys% Depletion > 13.89% = Active

Data Curation Template:

SARA-ICE - E. Reinke: Keratinosens

OECD 442D

Test chemicals are considered positive in the KeratinoSens™ if they induce a statistically significant induction of the luciferase activity above a given threshold (i.e. > 1.5 fold or 50% increase), below a defined concentration which does not significantly affect cell viability (i.e. below 1000 M and at a concentration at which the cellular viability is above 70%)

Check cases where max dose = EC3

Data Curation Template:

Verify thresholds correct

SARA-ICE - E. Reinke: HMT

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Data Curation Template:

HuSSPred - Human Skin Sensitization Data - WES HRIPT

DSA05

Select only:
- WES BIN

Level 3: Binary Only

• removes n/a
  
  

Chemical Curation

SARA-ICE - E. Reinke: HRIPT

.

Data Curation Template:

SARA-ICE - E. Reinke: H-Clat

OECD TG 442E -

Data Curation Template:

Investigate Tresholds

SARA-ICE - E. Reinke: U-SENS

Data Curation Template:

Investigate Threhsolds