HCS-Tools for KNIME version 4.0.0.v201906200802 by Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
The node computes the mutual information between two specified groups for a selected subset of parameter. Typically, in Hight Content Screening, a parameters quality can be judged by the mutual information between the library measurements and the reference measurments. the lower the mutual information value the more independent the distributions and thus the Library carries information the reference does not. The mutual information algorithm is a histogram based approach implemented according: "Moddemeijer R., A statistic to estimate the variance of the histogram based mutual information estimator based on dependent pairs of observations , Signal Processing, 1999, vol. 75, nr. 1, pp. 51-63"
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