The hydrophilic-lipophilic balance number (HLB number) measures the degree of a molecule being hydrophilic or lipophilic. This number is calculated based on identifying various hydrophil and liphophil regions in the molecule. This number is a commonly used descriptor in any workflow in which lipid based delivery can be an option. (e.g. lipid-based drug delivery, cosmetics) The HLB Predictor is a general tool for predicting the HLB number. It can predict the HLB number based on the Davies or the Griffin method.


  • ChemAxon: this is a consensus method based on the other two methods with optimal weights (default).
  • Davies: this is an extended version of the Davies method.
  • Griffin: this is an extended version of the Griffin method.
Structure column
The structure column.

Input Ports

Input table that contains structure in Structure(Mrv, Sdf, Smiles, etc.) format.

Output Ports

Output table that contains HLB.


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