TENSE T2P8 Legacy

Deterministic Layer: Pythagorean Switch

Quantification and phenotyping of dysregulated pathways through TENSE and DIRES calculations

• Semantic Layer: Reactome pathways derived from differential expression experiments are classified by an GPT4 as participating in DNA Damage, Inflammation, DNA repair, Epigenetic Drift and Nucleic Acid Sensing (DIRES).

• ,Deterministic Layer: DIRES classification and pathway scores are combined to calculate TENSE scores.

Input Layer

Semantic layer: LLM Think Tank (Currently Reasoner v1, Serial Array)