DRCfit_​biochemical_​ECBD

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DRC_biochemical_toECBD

This workflow can be used to fit dose-response curves from normalised biochemical assay data (%Inhibition) using the HCS extension. This workflow needs R-Server to run in the back-end. Start R and run the following command: library(Rserve); Rserve(args = "--vanilla")
IC50 values will not be extrapolated outside the tested concentration range
For activity classification the following criteria are applied:
- maximum (average % inhibion) >25 % and slope is >0 and IC50 > 5 µM or
- minimum (average % inhibion) >75 %
Results are formatted for upload to the European Chemical Biology Database (ECBD)

Nodes

• Column Expressions8 ×
• Column Filter3 ×
• GroupBy3 ×
• Column Rename2 ×
• Column Resorter2 ×
• Show all 16 nodes

Extensions

• FeatureKNIME Base nodes
• FeatureKNIME Column Expressions (legacy)
• FeatureKNIME HCS Tools
• FeatureKNIME Math Expression (JEP)

Links

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