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Path4Drug

Path4Drug

Path4Drug

This workflow connects drugs to their human type target proteins and enables a tissue-specific filtering as well. With the collected (tissue-specific) target proteins an overrepresentation test is being performed to see which biological pathways can be connected to the data. The workflow uses downloaded data and API calls.

Tissue Pathways Tissuemedium expression 10<Node 1177Node 1178Node 1180Node 1644Node 1645Node 1646Pathway BrowserNode 1648Report DownloadNode 1740Pathway_part1_TargetsNode 2007reviewed ckeckcompound_chembl_idNode 2129HUMANNode 2131reviewed and unreviwedNode 2133Node 2134tissue_specific_targetspathways, entities total, entities found, ratiobody: concatonated targetsNode 2138Node 2139FDRNode 2172Node 2173consensusexpression rateNode 2310 Column Filter Rule-basedRow Filter POST Request JSON Path Ungroup RowID Java Snippet GET Request String Manipulation Row Filter Binary Objectsto Files Rule-basedRow Filter Metanode GET Request String Manipulation List Box Input XPath Rule-basedRow Splitter Column Filter Rule-basedRow Splitter Joiner Column Filter GroupBy JSON Path POST Request Ungroup GroupBy Rule-basedRow Filter Column Filter GroupBy File Reader Rule-basedRow Filter RowID Tissue Pathways Tissuemedium expression 10<Node 1177Node 1178Node 1180Node 1644Node 1645Node 1646Pathway BrowserNode 1648Report DownloadNode 1740Pathway_part1_TargetsNode 2007reviewed ckeckcompound_chembl_idNode 2129HUMANNode 2131reviewed and unreviwedNode 2133Node 2134tissue_specific_targetspathways, entities total, entities found, ratiobody: concatonated targetsNode 2138Node 2139FDRNode 2172Node 2173consensusexpression rateNode 2310Column Filter Rule-basedRow Filter POST Request JSON Path Ungroup RowID Java Snippet GET Request String Manipulation Row Filter Binary Objectsto Files Rule-basedRow Filter Metanode GET Request String Manipulation List Box Input XPath Rule-basedRow Splitter Column Filter Rule-basedRow Splitter Joiner Column Filter GroupBy JSON Path POST Request Ungroup GroupBy Rule-basedRow Filter Column Filter GroupBy File Reader Rule-basedRow Filter RowID

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Extensions

Links

Download

To use this workflow in KNIME, download it from the below URL and open it in KNIME:

Download Workflow
Created by: fzbar
Created at: 2021-04-19
On NodePit since: 2021-10-01
Last update: 2024-11-23
Created with KNIME version: v4.1.2

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