HCS-Tools for KNIME version 4.0.0.v202007151505 by Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
For each chosen column (parameter) a reference population is used to estimate n different bins. The bins are based on the quantiles of the data. Then all data is grouped by the aggregation label (e.g. well) and the data of each group is applied to the bins. The percentage of data falling into a certain bin is calculated and used to estimate a z-score. The result contains a z-score, a percentage and an absolute count for each bin of each aggregation group and each parameter. It should help to detect minor distribution changes which would not be caught with a mean or median per aggregation group of the object data.
To use this node in KNIME, install KNIME HCS Tools from the following update site:
A zipped version of the software site can be downloaded here.
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