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Bioluminate 1-2

BioLuminate Residue Scanning

The antibody structure can be split into Fc, Fab and Fv domains. The node scans proteins for residues that are candidates for mutation and evaluate the stability and affinity of the mutated structures. Additionally, you can gain access to the latest command-line only functionalities of the tool (e.g., to control Prime loop sampling options), run affinity maturation and aggregation calculations that can be used to compare the mutants.

[Requires: Bioluminate]

BioLuminate Residue Scanning: The antibody structure can be split into Fc, Fab and Fv domains. The node scans proteins for residues that are candidates for mutation and evaluate the stabilityand affinity of the mutated structures. Additionally, you can gain access to the latest command-line only functionalities of the tool (e.g., to control Prime loopsampling options), run affinity maturation and aggregation calculations that can be used to compare the mutants.[Requires: Bioluminate]Antibody/Antigen complexKeep chains H,L,WBioluminate profileCartoon ribbons colored by antibody structureAll - A(ction) > Preset > Antibody Antibody structure split into Fc, Fab and FvBioluminate Delta Affinity and stability Command line optionsSplit antibody Regions Mutations H:103-105 Get PDB Protein PreparationWizard Delete Atoms Run Maestro Ungroup MAE Run Maestro Extract Properties Table Viewer Table Viewer ChemistryExternal Tool Concatenate (Optionalin) (deprecated) Table Viewer Ungroup MAE Residue Scanning Get Help BioLuminate Residue Scanning: The antibody structure can be split into Fc, Fab and Fv domains. The node scans proteins for residues that are candidates for mutation and evaluate the stabilityand affinity of the mutated structures. Additionally, you can gain access to the latest command-line only functionalities of the tool (e.g., to control Prime loopsampling options), run affinity maturation and aggregation calculations that can be used to compare the mutants.[Requires: Bioluminate]Antibody/Antigen complexKeep chains H,L,WBioluminate profileCartoon ribbons colored by antibody structureAll - A(ction) > Preset > Antibody Antibody structure split into Fc, Fab and FvBioluminate Delta Affinity and stability Command line optionsSplit antibody Regions Mutations H:103-105 Get PDB Protein PreparationWizard Delete Atoms Run Maestro Ungroup MAE Run Maestro Extract Properties Table Viewer Table Viewer ChemistryExternal Tool Concatenate (Optionalin) (deprecated) Table Viewer Ungroup MAE Residue Scanning Get Help

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To use this workflow in KNIME, download it from the below URL and open it in KNIME:

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Created by: jcmozzic
Created at: 2013-09-17
On NodePit since: 2020-02-17
Last update: 2020-02-26
Created with KNIME version: v4.1.0
Tags: ProteinBioluminate

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