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02 - Parallelization

Variant annotation: Parallelization - To speed up the annotation of large variant files, you can parallely align annotation modules and merge them again afterwards - Add additional input ports to the merge node (right click > Add ports > Input object (pickled)), then connect the nodes - Some nodes require pre-annotations of other nodes. In that case, make sure that the required nodes are aligned before the node. Example: 'Progtein features' requires pre-annotation with 'Protein_to_Genomic'. Make sure that 'Protein_to_Genomic' is run before 'Protein features'. ClinVar BFrame to_VCF VCF-Writer Variants Pathogenicity scores (all) VCF-Reader Protein features VCF _ to_ BFrame (GRCh38) Variant interpretation Conda Environment Protein_annotation Python Script Python Script CSV Writer Python Script File Reader Python Script Python Script Conda Environment Propagation Python Script Variant annotation: Parallelization - To speed up the annotation of large variant files, you can parallely align annotation modules and merge them again afterwards - Add additional input ports to the merge node (right click > Add ports > Input object (pickled)), then connect the nodes - Some nodes require pre-annotations of other nodes. In that case, make sure that the required nodes are aligned before the node. Example: 'Progtein features' requires pre-annotation with 'Protein_to_Genomic'. Make sure that 'Protein_to_Genomic' is run before 'Protein features'. ClinVar BFrame to_VCF VCF-Writer Variants Pathogenicity scores (all) VCF-Reader Protein features VCF _ to_ BFrame (GRCh38) Variant interpretation Conda Environment Protein_annotation Python Script Python Script CSV Writer Python Script File Reader Python Script Python Script Conda Environment Propagation Python Script

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To use this workflow in KNIME, download it from the below URL and open it in KNIME:

Download Workflow
Created by: nadine
Created at: 2025-07-10
On NodePit since: 2025-07-10
Last update: 2025-07-21
Created with KNIME version: v5.4.3

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