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Protein2Genome

Protein to Genome conversion - Use this workflow to convert sequence variant data from protein (e.g. 'BRAF:p.V600E') to genomic level ('chr7:g.140753336A>T') - Input: A CSV or TSV file, including a column 'gene' includiong HGNC gene symbols (e.g. 'BRAF'), and a column 'variant_exchange', including the amino acid exchange at protein level (e.g. 'V600E') - Annotation: Add a 'Protein_To_Genome' node to map protein positions to genomic positions - Output: You can write out the variant data at genomic level in various formats, including VCF, MAF or CSV CSV _ to_ BFrame CSV -Reader BFrame to_VCF VCF-Writer Variants MAF-Writer Variants BFrame to_MAF Protein_To _Genomic BFrame to_ CSV CSV-Writer Variants Conda Environment Python Script File Reader Python Script CSV Writer CSV Writer Python Script Python Script Python Script CSV Writer Conda Environment Propagation Protein to Genome conversion - Use this workflow to convert sequence variant data from protein (e.g. 'BRAF:p.V600E') to genomic level ('chr7:g.140753336A>T') - Input: A CSV or TSV file, including a column 'gene' includiong HGNC gene symbols (e.g. 'BRAF'), and a column 'variant_exchange', including the amino acid exchange at protein level (e.g. 'V600E') - Annotation: Add a 'Protein_To_Genome' node to map protein positions to genomic positions - Output: You can write out the variant data at genomic level in various formats, including VCF, MAF or CSV CSV _ to_ BFrame CSV -Reader BFrame to_VCF VCF-Writer Variants MAF-Writer Variants BFrame to_MAF Protein_To _Genomic BFrame to_ CSV CSV-Writer Variants Conda Environment Python Script File Reader Python Script CSV Writer CSV Writer Python Script Python Script Python Script CSV Writer Conda Environment Propagation

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To use this workflow in KNIME, download it from the below URL and open it in KNIME:

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Created by: nadine
Created at: 2025-06-04
On NodePit since: 2025-06-26
Last update: 2025-07-03
Created with KNIME version: v5.4.3

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